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Signs of Sepsis

Tips for evaluating a peripheral blood smear for possible sepsis

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References
  1. MedicineNet. Definition of sepsis. Available at: http://www.medterms.com/script/main/art.asp?articlekey=5449. Last accessed: 12/11/12.
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  4. The Merck Manual. Sepsis and septic shock. Available at: http://www.merckmanuals.com/professional/critical_care_medicine/sepsis_and_septic_shock/sepsis_and_septic_shock.html. Last accessed: 12/11/12.
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Signs of Sepsis

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Dear Sir,
Thank you for your feature article: Signs of Sepsis
with the concepts of toxic changes and the focus
provided by the two photomicrographs. May I also
suggest the following additional lab. tests to be
included, viz.:- Urinary Antigen Tests, ESR,
platelet count, C- Reactive Protein, and Blood
Culture Tests.
Ending here.
Thank you.
With warmest regards,

Yours sincerely,

Andrew Clarke

Andrew Clarke, FIBMS. MLT ,  MLT retired from Govt. ServiceJanuary 30, 2013
Sg. Petani, Kedah, Malaysia



The observations and advice given are helpful but it must be noted that granulocyte morphology deteriorates rapidly on storage in EDTA therefore the blood film must be prepared without delay, otherwise vacuolated cytoplasm and pyknotic nuclei may confuse the inexperienced microscopist.

Philip Day,  Retired Biomedical Scientist,  The General Infirmary at LeedsJanuary 30, 2013
Leeds UK



overwhelming sepsis can also present with a low white count and at times low platelets

barbara January 18, 2013
minneapolis, MN

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